up

   1. (of a male)

   copulating with

   Tout court and in a variety of vulgar phrases:

    'When you're up who, Barbara's down on whom?' asks Flora. 'Flora, you're coarse,' says Howard. (Bradbury, 1975)

   2. under the influence of illegal narcotics

   The result of getting high

    I knew one 4th Division Lurp who took his pills by the fistful, downs from the left pocket of his tiger suit and ups from the right. (Herr, 1977)